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One is Orlistat, a lipase inhibitor known by the name tetrahydrolipstatin and also by the marketing name Xenical. Xenical works by blocking the absorption of fat in the intestines by inhibiting pancreatic lipase. By inhibiting pancreatic lipase, triglycerides are excreted from the body in an undigested form. Xenical in clinical trials has allowed for study participants to lose ten percent of their body mass. The downsides to using Xenical, however, include gastrointestinal problems such as flatulence, oily stools, and increased bowel movements that may characterized as urgent. Additionally, Xenical interferes with the body's absorption of fat-soluble vitamins and micronutrients (fat soluble vitamins include vitamin A, vitamin D, vitamin K , and the carotenoids, such as beta-carotene).

A second obesity drug is sibutramine, marketed in the United States as Meridia and in Europe as Reductil. Sibutramine was approved by the FDA in 1997 as an anti-obesity drug and works by enhancing satiation (the sensation of feeling full) by blocking the reuptake of certain neurotransmitters (dopamine, norepinephrine, and serotonin). Sibutramine is chemically related to the appetite suppressant drug, phentermine. Phentermine, of course, was one of the two drugs contained in the anti-obesity pill Fen-phen (fenfluramine and phentermine) which was pulled off the market after Fen-phen was connected to reports of valvular heart disease.

Yet a third anti-obesity, weight loss pill is Rimonabant, marketed in the United Kingdom under the trade name Acomplia. Rimonabant works by suppressing appetite and by affecting the body's ability to store fat in the abdominal area.

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